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Jan 30, Retinitis pigmentosa: a common form of blindness (Papers Due)
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| One of the most common forms of Blindness is Retinitis Pigmentosa. Here are the initial papers that describe a molecular basis for this sort of blindness.
Question: Can you retrieve the opsin sequences from Genebank?
If you compare the sequences of fish, humans, rats, and cows, what are the differences, what are the similarities between the predicted proteins?
What does this mean, how do you interpret it?
Papers we will go over on thursday:
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| Rhodopsin mutations in autosomal dominant retinitis pigementosa
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| More than one mutation can cause RP. Why? Are they all causing the same problem?
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| A different gene can also cause retinitis pigmentosa? Why?
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 | Movies of lectures from Jeremy Nathans (contributed by Maggie Butler, thank you Maggie!)
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| Papers you might enjoy reading
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| The original cloning of human Rhodopsin
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| How do you turn off the photoresponse?
And what would happen if you couldn't?
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| And phosphodiasterase mutations can cause RP. Why?
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