6 Course Schedule & Topics Jan 16, An introduction to the course. Jan 19, No class, MLK day Jan 23, How do humans see color? (Papers Due) Jan 26, Hunting the genome to correlate phenotype and genotype Jan 30, Retinitis pigmentosa: a common form of blindness  (Papers Due) Feb 2, More thoughts about phototransduction so that we can understand CSNB Feb 6, Congenital Stationary Night Blindess.  (Papers Due) Feb 9, We haven't finished talking about Congenital Stationary Night Blindness. Feb 13, Talking about how science is done - a discussion about Popper and Kuhn   (Papers Due) Feb 16, Mouse technology, using mice to create models of human disease Feb 20, Can we use mouse models to better understand human color vision? (Papers Due) Feb 23, Huntington's chorea, a brief discussion of exon trapping. Feb 27, Huntington's chorea:  part 1 the disease, the gene and the genetics. (Papers Due) March 1, tool talk with Maggie Butler and Draggo. March 6, Huntington's disease part 2 (Papers Due) March 16 - 20, Spring break, a great time to re-write those papers. March 9, we trade papers for critiques March 13, we present each other's papers and talk about strengths and weaknesses of different approaches Spring Break, warm sun, travel to exotic places?  Or just stay home and get over our colds. March 23, SiRNA. March 27, SiRNA papers that attempt to knock down Huntingtin expression (Papers Due) March 30, Lecture on genetic screens in model organisms April 4, Models, suppressors, and mechanisms of the disease. (Papers Due) April 6, We will go over a few of the student papers today. April 10, No class, university holiday April 13, Better animal models of Huntington's disease? (Papers Due) April 17, Lets talk about parkinson's disease, apoptosis, and the paper that Dr. Lipton wants to go over. April 20, Master class with Dr. Stuart Lipton CFTR genetics, function, and a bit of curry May 2, Our last day.  All revised papers are due at this point.  Award ceremony for best paper title of the semester.