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March 27, SiRNA papers that attempt to knock down Huntingtin expression (Papers Due)
Some of you suggested this might be a good idea, and low and behold, Beverly Davidson thought so too!
but how would you get the siRNA into the brain???
How specific can you be in terms of silencing a particular gene?
Just in case you're curious, here's the original paper where they figured out why both sense and antisense RNA suppressed the response.   It's why the first and last authors were awarded the Nobel Prize.  
Check out Andrew Fire at: http://nobelprize.org/nobel_prizes/medicine/laureates/2006/fire-docu.html